R&D Services R&D Services

R&D Services

Basic PK

Pharmacokinetic (PK) study is to investigate ADME processes of drugs in the body by examining the time course of drug concentration profiles in readily accessible body fluids such as plasma and blood. A PK study is usually conducted via four steps, including drug dosing, sample collection, sample analysis, and PK calculation, as illustrated in the following scheme.
3D BioOptima can provide a broad spectrum of PK studies of small/large molecules, peptides, antibody-drug conjugates (ADC), and prodrugs.

Characteristics of the plan

  • Short Delivery Cycle

    Short Delivery Cycle

  • Various Experimental Species

    Various Experimental Species

  • Superior Analytical Skills

    Superior Analytical Skills

Experimental Design


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Laboratory

Animal Laboratory

Animal Laboratory

Bioanalytical Laboratory

Bioanalytical Laboratory

Cellular Laboratory

Cellular Laboratory

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Animal Laboratory

Animal Laboratory

The SPF and general animal rooms, with more than 600 square meters, can perform experiments on mice, rats, dogs, monkeys, rabbits, small pigs, and many other genera.

Experimental Content

Oral gavage, sublingual administration, injection, topical application, whole blood collection, excreta collection, tissue collection, eye tissue collection, cerebrospinal fluid collection, bile duct intubation, etc.

Experimental Advantages

A strict quality management system is in place to ensure the reliability of data and validity of research.

Bioanalytical Laboratory

Bioanalytical Laboratory

There are more than 400 sets of various instruments such as 16 sets of LC-MS/MS systems, 2 sets of MSD, analytical balances of 1 part in a million and 1 part in 100,000, respiratory anesthesia machines, IVC systems, various incubators, tissue homogenizers, centrifuges and so on.

Experimental Content

In vitro metabolic studies, including metabolic studies based on liver microsomes, hepatocytes, liver S9, CYP enzymes, etc;
Analysis of biological samples for PK, tissue distribution and excretion experiments, development and validation of analytical methods, parameter calculations, etc.

Experimental Advantages

The laboratory follows GLP (Good Laboratory Practice) and ISO standards to ensure data reliability and accuracy.

Cellular Laboratory

Cellular Laboratory

More than 100 bead cell banks have been established.

Experimental Content

In vitro cell proliferation inhibition, Caco-2 permeability, and hepatocyte-related experimental studies can be performed.

Experimental Advantages

The laboratory has a cell bank of more than 100 beads. The laboratory strictly follows the experimental practice to ensure the accuracy and reproducibility of the data.

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