Metabolic dysfunction-associated steatohepatitis (MASH), previously known as non-alcoholic steatohepatitis (NASH), is a pathological condition similar to alcoholic hepatitis but in the absence of excessive alcohol consumption. It represents an extreme progression of non-alcoholic fatty liver disease (NAFLD), characterized by fat degeneration with inflammation and hepatocyte damage. Some patients may eventually develop cirrhosis and hepatocellular carcinoma. MASH has been identified by FirstWord as one of the top 10 disease areas or drug categories that are expected to be the main focus and competition for new drug development in the next decade. Shengsu Biopharma has established stable MASH mouse models induced by CDAHFD and AMLN, which can provide in vivo efficacy validation models for the screening and development of related compounds.
CDAHFD诱导小鼠模型
AMLN诱导小鼠模型
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The SPF and general animal rooms, with more than 600 square meters, can perform experiments on mice, rats, dogs, monkeys, rabbits, small pigs, and many other genera.
Oral gavage, sublingual administration, injection, topical application, whole blood collection, excreta collection, tissue collection, eye tissue collection, cerebrospinal fluid collection, bile duct intubation, etc.
A strict quality management system is in place to ensure the reliability of data and validity of research.
There are more than 400 sets of various instruments such as 16 sets of LC-MS/MS systems, 2 sets of MSD, analytical balances of 1 part in a million and 1 part in 100,000, respiratory anesthesia machines, IVC systems, various incubators, tissue homogenizers, centrifuges and so on.
In vitro metabolic studies, including metabolic studies based on liver microsomes, hepatocytes, liver S9, CYP enzymes, etc;
Analysis of biological samples for PK, tissue distribution and excretion experiments, development and validation of analytical methods, parameter calculations, etc.
The laboratory follows GLP (Good Laboratory Practice) and ISO standards to ensure data reliability and accuracy.
More than 100 bead cell banks have been established.
In vitro cell proliferation inhibition, Caco-2 permeability, and hepatocyte-related experimental studies can be performed.
The laboratory has a cell bank of more than 100 beads. The laboratory strictly follows the experimental practice to ensure the accuracy and reproducibility of the data.
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