Metabolic stability refers to the susceptibility of compounds to biotransformation and therefore influences oral bioavailability and systemic half-life of a compound, which in turn, affect its safety and efficacy profiles. As the major elimination pathway for most drugs, metabolism is achieved via two major enzyme reactions within the liver, Phase I and Phase II reactions.
Metabolic stability is often assessed in-vitro in liver microsomes, hepatocytes, and/or S9 fractions. After the incubation of compound(s) in the selected system (usually liver microsomes), samples are collected at different time points. Then remaining parent will be quantified, followed by calculation of half-life (T1/2) and intrinsic clearance (Clint).
3D BioOptima can provide metabolic stability studies of compounds in liver microsomes, hepatocytes, and S9 fractions.
You can contact us through the right side, we will assign a professional consultant to answer your questions.
The SPF and general animal rooms, with more than 600 square meters, can perform experiments on mice, rats, dogs, monkeys, rabbits, small pigs, and many other genera.
Oral gavage, sublingual administration, injection, topical application, whole blood collection, excreta collection, tissue collection, eye tissue collection, cerebrospinal fluid collection, bile duct intubation, etc.
A strict quality management system is in place to ensure the reliability of data and validity of research.
There are more than 400 sets of various instruments such as 16 sets of LC-MS/MS systems, 2 sets of MSD, analytical balances of 1 part in a million and 1 part in 100,000, respiratory anesthesia machines, IVC systems, various incubators, tissue homogenizers, centrifuges and so on.
In vitro metabolic studies, including metabolic studies based on liver microsomes, hepatocytes, liver S9, CYP enzymes, etc;
Analysis of biological samples for PK, tissue distribution and excretion experiments, development and validation of analytical methods, parameter calculations, etc.
The laboratory follows GLP (Good Laboratory Practice) and ISO standards to ensure data reliability and accuracy.
More than 100 bead cell banks have been established.
In vitro cell proliferation inhibition, Caco-2 permeability, and hepatocyte-related experimental studies can be performed.
The laboratory has a cell bank of more than 100 beads. The laboratory strictly follows the experimental practice to ensure the accuracy and reproducibility of the data.
Copyright © 2024 3D BioOptimaSu ICP No. 13029454
Customer first, customer satisfaction!
Customer First, Customer Satisfaction!
